Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling
نویسندگان
چکیده
منابع مشابه
Regulation of neuronal cell death by MST1-FOXO1 signaling.
The protein kinase mammalian Sterile 20-like kinase 1 (MST1) plays a critical role in the regulation of cell death. Recent studies suggest that MST1 mediates oxidative stress-induced neuronal cell death by phosphorylating the transcription factor FOXO3 at serine 207, a site that is conserved in other FOXO family members. Here, we show that MST1-induced phosphorylation of FOXO1 at serine 212, co...
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Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. The protein kinase MST1 (mammalian Ste20-like kinase 1) plays a major role in oxidative stress-induced cell death in primary mammalian neurons. However, the mechanisms that regulate MST1 in oxidative stress responses remain largely unknown....
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Thank you for submitting your manuscript to the EMBO journal. Your study has now been seen by three referees and their comments are provided below. As you can see the referees appreciate that we gain insight into the role of the Hippo pathway in microglia function and find the analysis interesting. They raise a number of important points that would have to be addressed for further consideration...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m900461200